核酸纳米技术与细胞调控；

功能核酸纳米药物的智能生物医疗应用；

主要从事生物纳米材料的研究工作，致力于开发基于核酸信号扩增的癌症诊断新方法。在功能核酸用于生化分析和细胞调控领域做出了一系列研究成果，相关工作以第一作者或通讯作者在Angewandte Chemie International Edition, Nature Communications, Chemical Science, Analytical Chemistry等国内外学术刊物上发表论文共计14篇。主持国家自然科学基金1项，省部级科研项目2项。

[1] Xue Gong, Ruomeng Li, Jing Wang, Jie Wei, Kang Ma, Xiaoqing Liu, Fuan Wang*. A smart theranostic nanocapsule for spatiotemporally programmable photo-genetherapy. Angew. Chem. Int. Ed., 2020, 59, 21648-21655.

[2] Xue Gong, Haizhou Wang, Ruomeng Li, Jie Wei, Jing Wang, Chen Hong, Xiaoqing Liu, Jing Liu, Fuan Wang*. A smart multi-antenna gene theranostic system based on the programmed assembly of hypoxia-related siRNA. Nat. Commun., 2021, 12, 3953.

[3] Xue Gong, Shizhen He, Ruomeng Li, Yingying Chen, Kaiyue Tan, Yeqing Wan, Xiaoqing Liu, Fuan Wang*. Monitoring and modulating a catalytic hybridization circuit for self-adaptive bioorthogonal DNA assembly. Chem. Sci., 2022, 13, 10428-10436.

[4] Xue Gong, Jie Wei, Ruomeng Li, Jing Liu, Xiaoqing Liu, Fuan Wang*. Programmable intracellular DNA biocomputing circuits for reliable cell recognitions. Chem. Sci., 2019, 10, 2989-2997.

[5] Xue Gong*,#, Jiajia Zhang#, Pu Zhang, Yuqian Jiang, Lianzhe Hu, Zhongwei Jiang, Fuan Wang*, Yi Wang*. Engineering of a Self-Regulatory Bidirectional DNA Assembly Circuit for Amplified MicroRNA Imaging. Anal. Chem., 2023, 95, 18731-18738.

[6] Chenxia Xie, Ruomeng Li, Xue Gong*, Qingqing Zhang, Yanping Zhang, Zeyue Wang, Xiaoqing Liu, Fuan Wang*. Efficient Intracellular MicroRNA Imaging Based on the Localized and Self-Sustainable Catalytic DNA Assembly Circuit. Anal. Chem., 2023, 95, 10398-10404.

[7] Ruomeng Li#, Xue Gong #, Chen Hong, Hong Wang, Yingying Chen, Kaiyue Tan, Xiaoqing Liu, Fuan Wang*. An efficient photochemotherapy nanoplatform based on the endogenous biosynthesis of photosensitizer in macrophage-derived extracellular vesicles. Biomaterials, 2021, 279, 121234.